Preliminary investigation on polymorphs of two traditional Chinese medicine reference substances.
- Author:
Li-xing NIE
;
Ye ZHANG
;
Zhong DAI
;
Yi ZHANG
;
Shuang-cheng MA
- Publication Type:Journal Article
- MeSH:
Crystallization;
Differential Thermal Analysis;
methods;
standards;
Drugs, Chinese Herbal;
chemistry;
standards;
Medicine, Chinese Traditional;
Molecular Structure;
Reference Standards;
Spectrophotometry, Infrared;
methods;
standards;
Transition Temperature
- From:
China Journal of Chinese Materia Medica
2015;40(16):3245-3248
- CountryChina
- Language:Chinese
-
Abstract:
Crystal structures of chemical drugs has been being investigated widely. But few attention has been paid to polymorphs-phenomena of active ingredients from Traditional Chinese Medicine(TCM). Taking anhydrous dehydroandrographolide and hydrousprim-O-glucosylcimifugin as example, differences between TCM reference substances (RSs) with different crystal structures were discussed by using microscopy, melting point determination, differential thermal analysis (DTA) and infrared (IR) methods. The results showed that different crystal structures could lead to change of melting points, thermal behaviors and IR spectrum. It's indicated that polymorphs may be considered if different physicochemical properties were obtained when applying TCM RS. Differences of chemical properties of active ingredients from TCM with different crystal structures need further investigation.
