Pharmacokinetic effect of combined administration on spinosin and ferulic acid in monarch drug Ziziphi Spinosae Semen kernel.
- Author:
Rong GAO
;
Shan LI
;
Xian-jin CHEN
;
Xiao-feng WANG
;
Shi-xiang WANG
;
Min-feng FANG
- Publication Type:Journal Article
- MeSH:
Animals;
Chromatography, High Pressure Liquid;
Coumaric Acids;
administration & dosage;
blood;
pharmacokinetics;
Drug Interactions;
Drugs, Chinese Herbal;
administration & dosage;
analysis;
pharmacokinetics;
Female;
Flavonoids;
administration & dosage;
blood;
pharmacokinetics;
Humans;
Male;
Rats;
Rats, Sprague-Dawley;
Ziziphus;
chemistry
- From:
China Journal of Chinese Materia Medica
2015;40(16):3293-3297
- CountryChina
- Language:Chinese
-
Abstract:
To study the pharmacokinetic effect of different combined administration with monarch drug Ziziphi Spinosae Semen on its main components in rats. Sprague-Dawley (SD) rats were randomly divided into Ziziphi Spinosae Semen group, Ziziphi Spinosae Semen-Fructus Schisandrae Chinensis group, Ziziphi spinosae Semen-Salviae Miltiorrhize Radix et Rhizoma group and Zaoren Ansheng prescription group. After oral administration, HPLC was eluted with the mobile phase of acetonitrle-0.03% phosphate acid water in a gradient mode. The detection wavelength was 280 nm. The pharmacokinetic parameters of spinosin and ferulic acid were calculated by DAS 2. 0 software. Compared with Ziziphi Spinosae Semen group, Ziziphi Spinosae Semen-Fructus Schisandrae Chinensis group, Ziziphi Spinosae Semen-Salviae miltiorrhizae Radix et Rhizoma group showed a lower maximum plasma concentration (C(max)) and area under curve (AUC(0-t)) for spinosin and ferulic acid but higher clearance speed (CL/F); whereas the Zaoren Ansheng prescription group showed higher maximum plasma concentration (C(max)) and area under curve (AUC(0-t)) for spinosin and ferulic acid but lower clearance speed (CL/F). Compared with Ziziphi Spinosae Semen group, prescription group showed slower metabolism of spinosin and ferulic
