Preparation and in vitro dissolution of magnolol solid dispersion.

Author: Lan TANG ¹ ; Shuai-Bo QIU ¹ ; Lan WU ¹ ; Long-Fei LV ¹ ; Hui-Xia LV ² ; Wei-Guang SHAN ¹
Author Information

1. School of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.
2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Publication Type:Journal Article
Keywords: croscarmellose sodium; dissolution; magnolol; solid dispersion; stability
From: China Journal of Chinese Materia Medica 2016;41(3):433-437
CountryChina
Language:Chinese
Abstract: In this study, solid dispersion system of magnolol in croscarmellose sodium was prepared by using the solvent evaporation method, in order to increase the drug dissolution. And its dissolution behavior, stability and physical characteristics were studied. The solid dispersion was prepared with magnolol and croscarmellose sodium, with the proportion of 1∶5, the in vitro dissolution of magnolol solid dispersion was up to 80.66% at 120 min, which was 6.9 times of magnolol. The results of DSC (differential scanning calorimetry), IR (infra-red) spectrum and SEM (scanning electron microscopy) showed that magnolol existed in solid dispersion in an amorphous form. After an accelerated stability test for six months, the drug dissolution and content in magnolol solid dispersion showed no significant change. So the solid dispersion prepared with croscarmellose sodium as the carrier can remarkably improve the stability and dissolution of magnolol.