Optimization of flash-type extraction technology of alisol B 23-acetate from Alismatis Rhizoma by response surface methodology.
- Author:
Ying-Chun WEI
1
;
Ming YAN
1
;
Jing YANG
1
;
Jun-Chao LIU
1
;
Hong-Mei YIN
1
;
Yun WU
1
;
Yong-Cheng SUN
1
;
Wei XIAO
1
Author Information
- Publication Type:Journal Article
- Keywords: alisol B 23-acetate; flash-type extraction; response surface methodology
- From: China Journal of Chinese Materia Medica 2016;41(3):438-442
- CountryChina
- Language:Chinese
- Abstract: Response surface methodology was used to optimize and obtain the optimal flash-type extraction technology of alisol B 23-acetate from Alismatis Rhizoma. With the extraction rate of alisol B 23-acetate as an indicator, single-factor test was used to investigate the effect of ethanol volume fraction, liquid-solid ratio, extraction times and extracting time on the extraction rate of alisol B 23-acetate.The results were combined with Box-Benhnken design and response surface analysis to optimize the technology parameters for extraction process of Alismatis Rhizoma and obtain the optimal flash-type extraction technology under the following conditions: ethanol volume fraction 80%, liquid-solid ratio 12∶1, extraction 4 times, 114 s/time. Flash-type extraction technology of alisol B 23-acetate by response surface methodology is stable, time-saving, efficient, and with the advantages of room temperature extraction and no component damage, so it can be used for massive production.