Updated Relationship of microRNA with male reproduction.
- Author:
Xiao-dong HAN
;
Yuan ZHOU
- Publication Type:Journal Article
- MeSH:
Biomarkers;
Cell Differentiation;
Genitalia, Male;
Germ Cells;
Humans;
Infertility, Male;
Male;
MicroRNAs;
genetics;
RNA Interference;
Semen;
physiology;
Spermatogenesis;
genetics
- From:
National Journal of Andrology
2015;21(11):963-966
- CountryChina
- Language:Chinese
-
Abstract:
Spermatogenesis is a unique process of cell differentiation, which involves the regulation of a series of complicated post-transcriptional expressions. MicroRNAs (miRNAs) are a class of none-coding RNAs that play important roles in regulating post-transcriptional gene silencing. MiRNAs are expressed in a cell-specific manner in spermatogenesis and participate in the maturation and differentiation of male germ cells. The specifically altered seminal plasma miRNA is closely related with spermatogenic dysfunction and therefore can be used as a novel biomarker for the diagnosis of male infertility. A deeper insight into these specific miRNAs may point a new direction in the studies of the molecular mechanisms of spermatogenesis and spermatogenic dysfunction.
