Expression ratio of the nerve growth factor receptor TrkA to p75NTR correlates with the clinical stage and pathological grade of prostate cancer.
- Author:
Jie YANG
;
Jia-yi ZHANG
;
Ya-min WANG
;
Peng-fei SHAO
;
Ning-hong SONG
;
Li-xin HUA
;
Wei ZHANG
- Publication Type:Journal Article
- MeSH: Humans; Immunohistochemistry; Male; Neoplasm Grading; Neoplasm Staging; Nerve Tissue Proteins; metabolism; Prognosis; Prostatic Hyperplasia; pathology; Prostatic Neoplasms; pathology; Receptor, trkA; metabolism; Receptors, Nerve Growth Factor; metabolism; Up-Regulation
- From: National Journal of Andrology 2015;21(11):982-987
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions and action mechanisms of nerve growth factor (NGF) receptors TrkA and p75NTR in the oncogenesis and progression of prostate cancer (PCa).
METHODSUsing immunohistochemistry, we detected the expressions of TrkA and p75NTR in 62 PCa and 35 benign prostatic hyperplasia (BPH) samples, and conducted statistical analysis on the basis of clinical data.
RESULTSIndependent-samples t-test showed that, along with poorer tissue differentiation or higher clinical stage of PCa, the expression of TrkA was significantly up-regulated, that of p75NTR remarkably down-regulated, and the expression ratio of TrkA to p75NTR markedly increased. The TrkA/p75NTR ratio was 0.32 in the BPH, 0.52 in the PCa tissue with Gleason score of 6, 1.65 in the PCa tissue with Gleason score of 7, 5.75 in the PCa tissue with Gleason score ≥ 8, 0.89 in the clinical stage of pT2, 1.5 in pT3 a, 3.75 in pT3b, and 7.00 in pTxN1.
CONCLUSIONThe abnormally increased expression ratio of TrkA to p75NTR might be one of the essential features of malignant transformation of prostate cells. A higher TrkA/p75NTR expression ratio may be associated with a lower tissue differentiation, a higher clinical stage or Gleason score, and therefore a poorer prognosis.