Non-coding RNAs in castration-resistant prostate cancer.
- Author:
Guo-ping XIE
;
Rui JIANG
- Publication Type:Journal Article
- MeSH:
Humans;
Male;
MicroRNAs;
genetics;
Prostatic Neoplasms, Castration-Resistant;
genetics;
RNA, Untranslated;
genetics
- From:
National Journal of Andrology
2015;21(11):1014-1019
- CountryChina
- Language:Chinese
-
Abstract:
Non-coding RNAs (ncRNAs) are a large class of RNA molecules that do not encode proteins, regulate gene expressions multifacetedly, and influence the metabolism, proliferation, differentiation and apoptosis of cells as well as the occurrence and progression of tumors. Some of the ncRNAs act as cancer genes, such as miR-19a, miR-125b, miR-616, miR-7, miR-221, MALAT-1, and PRNCR1, which are upregulated in castration-resistant prostate cancer (CRPC) tissues or cell lines, and promote the development and progression of CRPC, some act as tumor suppressor genes, including miR-185, miR-342, miR-15, miR-16, and miR-146, which are downregulated in CRPC tissues or cell lines and inhibit or delay the occurrence of CRPC, and still others, such as miR-7, miR-19a, miR-125b, miR-221, and MALAT-1, are differentially expressed in the serum or tissue and can be used as potential biomarkers for the early diagnosis and prognosis of CRPC. This article presents an overview on the roles of ncRNAs in the occurrence, progression, diagnosis, and prognosis of CRPC and advances in their studies.
