Reproducibility of Gleason scores in prostate cancer.
- Author:
Hui-jie HE
;
Gong-wei WANG
- Publication Type:Journal Article
- MeSH: Carcinoma; diagnosis; Humans; Male; Neoplasm Grading; Prostatic Neoplasms; diagnosis; Reproducibility of Results
- From: National Journal of Andrology 2016;22(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the reproducibility of Gleason scores for prostate cancer.
METHODSBased on the revised Gleason Scoring System of the International Society of Urological Pathology ( ISUP) , we analyzed the reproducibility and difference of Gleason scores in 49 cases of prostate cancer using the methods of combination and grouping.
RESULTSThe total reproducibility of Gleason scores among 15 pathologists was good (κ = 0.642), 62.2% by the combination method, the highest in Gleason 5 + 5 (81.2%) and 5 +4 (73.3%), then in Gleason 4 + 4 (67.5%), 3 + 3 (64.0%), 4 +3 (61.3%), and 3 + 4 (44.0%), and the lowest in Gleason 4 + 5 (38.9%) and 3 + 5 (33.3%). The total reproducibility of Gleason scores by the grouping method was 71.4%, the highest in Gleason 9-10 (84.9%) , then in Gleason 7 (76.7%) and 6 (64.0%), and the lowest in Gleason 8 (60.7%).
CONCLUSIONThe reproducibility of Gleason scores remains to be further improved in prostate cancer, mainly concerning the understanding of Gleason 3 and 4 carcinoma.