Relationship of MTHFR gene polymorphisms with infertility.
- Author:
Kai-min GUO
;
Run-hui TIAN
;
Hong-liang WANG
- Publication Type:Journal Article
- MeSH:
DNA;
biosynthesis;
DNA Methylation;
DNA Repair;
Folic Acid;
metabolism;
Homocysteine;
metabolism;
Humans;
Infertility;
enzymology;
genetics;
Methylenetetrahydrofolate Reductase (NADPH2);
genetics;
Polymorphism, Genetic;
Prospective Studies
- From:
National Journal of Andrology
2016;22(2):171-174
- CountryChina
- Language:Chinese
-
Abstract:
The folate metabolic pathway plays important roles in cellular physiology by participating in nucleotide synthesis, DNA repair and methylation, and maintenance and stability of the genome. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme involved in folate metabolism. Polymorphisms of MTHFR may change the level of homocysteine and affect DNA synthesis and methylation, leading to an increased oxidative stress and disturbed methylation reactions and consequently affecting reproductive function. This article presents an overview on MTHFR gene polymorphisms, proposing that multicentered, large-sample and long-term prospective studies are needed to reveal the relationship between MTHFR gene polymorphisms and infertility.
