Roles of G protein-coupled estrogen receptor in the male reproductive system.
- Author:
Kai-hong CHEN
;
Xian ZHANG
;
Xue-wu JIANG
- Publication Type:Journal Article
- MeSH:
Estrogens;
metabolism;
Genitalia, Male;
metabolism;
Humans;
Male;
Molecular Structure;
Organ Specificity;
Receptors, Estrogen;
chemistry;
physiology;
Receptors, G-Protein-Coupled;
chemistry;
physiology;
Reproduction;
physiology;
Signal Transduction
- From:
National Journal of Andrology
2016;22(2):175-179
- CountryChina
- Language:Chinese
-
Abstract:
The G protein-coupled estrogen receptor (GPER), also known as G protein-coupled receptor 30 (GPR30), was identified in the recent years as a functional membrane receptor different from the classical nuclear estrogen receptors. This receptor is widely expressed in the cortex, cerebellum, hippocampus, heart, lung, liver, skeletal muscle, and the urogenital system. It is responsible for the mediation of nongenomic effects associated with estrogen and its derivatives, participating in the physiological activities of the body. The present study reviews the molecular structure, subcellular localization, signaling pathways, distribution, and function of GPER in the male reproductive system.
