Animal models of autoimmune prostatitis and their evaluation criteria.
- Author:
Jia-ming SHEN
;
Jin-chun LU
;
Bing YAO
- Publication Type:Journal Article
- MeSH:
Animals;
Autoimmune Diseases;
etiology;
pathology;
Chronic Disease;
Disease Models, Animal;
Humans;
Male;
Prostatitis;
etiology;
immunology;
pathology;
Transcription Factors
- From:
National Journal of Andrology
2016;22(3):268-272
- CountryChina
- Language:Chinese
-
Abstract:
Chronic prostatitis is a highly prevalent disease of unclear etiology. Researches show that autoimmune reaction is one cause of the problem. An effective animal model may help a lot to understand the pathogenesis and find proper diagnostic and therapeutic strategies of the disease. Currently used autoimmune prostatitis-related animal models include those of age-dependent spontaneous prostatitis, autoimmune regulator-dependent spontaneous prostatitis, self antigen-induced prostatitis, and steroid-induced prostatitis. Whether an animal model of autoimmune prostatitis is successfully established can be evaluated mainly from the five aspects: histology, morphology, specific antigens, inflammatory factors, and pain intensity.
