Reduced zinc concentration in expressed prostatic secretion relates to the pain symptoms of types Ⅲ and Ⅳ prostatitis.

Lin-jian MO; Xi Chen; Xiao-ming Wang; Guang-yu LI; Xun Zhang; Shan Huang; Zhi-bin Xie; Zeng-nan MO

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Reduced zinc concentration in expressed prostatic secretion relates to the pain symptoms of types Ⅲ and Ⅳ prostatitis.

Author: Lin-Jian MO ¹ ; Xi CHEN ¹ ; Xiao-Ming WANG ¹ ; Guang-Yu LI ² ; Xun ZHANG ² ; Shan HUANG ³ ; Zhi-Bin XIE ¹ ; Zeng-Nan MO ¹
Author Information

1. Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
2. Department of Andrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
3. Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Publication Type:Journal Article
Keywords: correlation; expressed prostatic secretion; pain symptom; type Ⅲ; type Ⅳ; typing of prostatitis; zinc
MeSH: Adolescent; Adult; Aged; Chronic Disease; Humans; Male; Middle Aged; Pain; metabolism; Prostatitis; metabolism; physiopathology; Quality of Life; Young Adult; Zinc; metabolism
From: National Journal of Andrology 2016;22(6):496-500
CountryChina
Language:Chinese
Abstract:
ObjectiveTo determine the zinc levels in the expressed prostatic secretion (EPS) of the patients with different types of chronic nonbacterial prostatitis, and explore the reference value of zinc concentration in EPS in the diagnosis and treatment of prostatitis.
METHODSWe collected EPS samples from 35 healthy men and 173 patients with chronic nonbacterial prostatitis, including 65 cases of type ⅢA, 69 cases of type ⅢB, and 39 cases of type Ⅳ, according to the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). We compared the zinc levels in the EPS samples among different groups and analyzed the correlations of zinc concentration with the NIH-CPSI scores, WBC count, pH value, and age of the subjects.
RESULTSThe participants were aged 17－65 (32.5±8.5) years. The zinc concentrations in the EPS were significantly lower in the ⅢA (［162.2±10.8］ μg/ml) and ⅢB (［171.2±12.0］ μg/ml) than in the Ⅳ (［234.6±17.9］ μg/ml) (P<0.05 ) and the control group (［259.5±14.6］ μg/ml) (P<0.05 ). The zinc level was correlated negatively with the NIH-CPSI pain score (r=－0.248, P<0.01), quality of life score (r=－0.232, P<0.01), severity score (r=－0.270, P<0.01), total NIH-CPSI score (r=－0.281, P<0.01), and the pH value in EPS (r=－0.208, P<0.01), but showed no correlation with the WBC count and age of the subjects.
CONCLUSIONSThe reduced zinc concentration in the EPS of the patients with chronic nonbacterial prostatitis may be associated with the pain symptoms of the disease, which suggests the potential reference value of measuring the zinc concentration in EPS in the diagnosis and treatment of prostatitis.