Correlation of high-risk HPV 16/18 infections with prostate cancer.

Lin Huang; Ming-gui WU; Juan HE; Zheng-shu Wei; Wen-xin LÜ; Xu-jia Song; Yan Zhang; Shang-xin WU; You-le Yin; Yong-yi Fan

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Correlation of high-risk HPV 16/18 infections with prostate cancer.

Author: Lin HUANG ¹ ; Ming-Gui WU ¹ ; Juan HE ² ; Zheng-Shu WEI ¹ ; Wen-Xin LÜ ¹ ; Xu-Jia SONG ¹ ; Yan ZHANG ¹ ; Shang-Xin WU ¹ ; You-le YIN ¹ ; Yong-Yi FAN ¹
Author Information

1. Department of Urology, The 4th Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545005, China.
2. Department of Pathology, The 4th Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545005, China.
Publication Type:Journal Article
Keywords: correlation; human papillomavirus 16/18; prostate cancer
MeSH: Human papillomavirus 16; Human papillomavirus 18; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Neoplasm Grading; Papillomavirus Infections; epidemiology; Polymerase Chain Reaction; Prostatic Hyperplasia; epidemiology; virology; Prostatic Neoplasms; epidemiology; virology
From: National Journal of Andrology 2016;22(6):501-505
CountryChina
Language:Chinese
Abstract:
ObjectiveTo study the correlation of high-risk human papillomavirus 16 and 18 (HPV16/18) infections with the risk of prostate cancer (PCa) and their association with the clinicopathologic indexes of PCa.
METHODSWe collected tissue samples from 75 cases of PCa and 73 cases of benign prostatic hyperplasia (BPH). We detected HPV16/18 infections in the samples by immunohistochemistry and PCR combined with reverse dot blot (RDB) assay.
RESULTSImmunohistochemistry revealed 16 cases of HPV16/18 positive in the PCa (21.3%) and 7 cases in the BPH samples (9.5%), with statistically significant difference between the two groups (P=0.049). PCR combined with RDB assay showed 17 cases of HPV16 infection (22.6%) and 13 cases of HPV18 infection (17.8%), including 4 cases of HPV16/18 positive, in the PCa group, remarkably higher than 6 cases of HPV16 infection (8.2%), 3 cases of HPV18 infection (4.1%) and no HPV16/18 positive in the BPH controls (P=0.001). No significant differences were observed between the result of immunohistochemistry and that of PCR combined with RDB assay (P=0.069). The risk of HPV16/18 infections was found to be correlated with the clinical T-stage and Gleason score of PCa (P<0.05 ) but not with the patient's age, PSA level or lymph node metastasis (P>0.05 ).
CONCLUSIONSHigh-risk HPV16/18 infections are correlated with the risk of prostate cancer.