Kangle Decoction for erectile dysfunction with liver-qi stagnation and kidney deficiency.
- Author:
Qiang CHEN
1
;
Yong ZHU
2
;
Ming-Yue ZENG
3
;
Kai YANG
4
;
Jian HUANG
5
;
Ting-Song BIAN
6
;
Jin-Song WANG
7
;
Qing-Qi ZENG
5
Author Information
- Publication Type:Journal Article
- Keywords: Kangle decoction; erectile dysfunction; erectile dysfunction inventory of treatment satisfaction; international index of erectile function-5; psychological and interpersonal relationship scales
- MeSH: Adult; Drugs, Chinese Herbal; therapeutic use; Erectile Dysfunction; drug therapy; Humans; Male; Middle Aged; Patient Satisfaction; Qi; Self Concept; Sexual Behavior; Tadalafil; therapeutic use; Treatment Outcome
- From: National Journal of Andrology 2016;22(6):538-542
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical efficacy of Kangle Decoction in the treatment of erectile dysfunction (ED) with liver-qi stagnation and kidney deficiency.
METHODSA total of 79 ED patients with liver-qi stagnation and kidney deficiency were randomly assigned to an experimental group (aged ［36.62±8.05］ yr and with a disease course of ［18.15±6.41］ mo) and a control group (aged ［37.44±8.10］ yr and with a disease course of ［17.51±6.79］ mo), the former treated orally with Kangle Decoction at 0.5 dose bid while the latter with Cialis at 10 mg qd alt, both for 8 weeks. Before treatment, after 4 and 8 weeks of medication, and at 4 weeks after drug withdrawal, we obtained the scores of the patients in the International Index of Erectile Function-5 (IIEF-5), Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS), and Short-Form Psychological and Interpersonal Relationship Scales (SF-PAIRS), and compared the indexes between the two groups of patients.
RESULTSThe IIEF-5 score was dramatically increased in both the treatment and control groups after 4 weeks (13.40±2.42 and 16.00±2.68) and 8 weeks of medication (18.60±3.50 and 18.59±3.80) and at 4 weeks after drug withdrawal (17.00±3.05 and 13.95±2.61) as compared with the baseline (10.78±2.28 and 10.77±2.33) (P<0.05 ), even higher in the treatment than in the control group after drug withdrawal (P<0.05 ). The EDITS scores in the treatment and control groups were (28.88±3.31 and 28.90±3.31) after 4 weeks of intervention, (29.68±3.30 and 29.13±3.32) after 8 weeks of intervention, and (29.20±2.92 and 26.82±3.23) at 4 weeks after drug withdrawal, all significantly higher in the former than in the latter group after drug withdrawal (P<0.05 ). The sexual self-confidence score (SSCS), sexual spontaneity score (SSS), and sexual time-concern score (STCS) were all improved in the treatment and control groups after medication as compared with the baseline (P<0.05 ), even higher in the former than in the latter group after drug withdrawal (P<0.05 ).
CONCLUSIONSKangle Decoction has a definite efficacy in the treatment of ED with liver-qi stagnation and kidney deficiency, with few adverse reactions and long-term post-withdrawal effect, and therefore deserves a wide clinical application.
