Efficiency of lactose-free formula feeding as an adjunctive therapy in infants with acute diarrhea.
- Author:
Jia-Hua XU
1
;
Ying HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Diarrhea, Infantile; microbiology; therapy; Double-Blind Method; Female; Humans; Infant; Infant Formula; Infant, Newborn; Intestines; microbiology; Lactose; Male
- From: Chinese Journal of Contemporary Pediatrics 2009;11(7):532-536
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the efficiency of lactose-free formula feeding as an adjunctive therapy in infants with acute diarrhea.
METHODSA rigorous double-blind, randomized, controlled equivalence trial was performed. One hundred and twenty infants with acute diarrhea were randomly divided into two groups: lactose-free formula and conventional formula feeding. The two groups were given conventional medical treatment and oral rehydration therapy. The therapeutic effects were observed 1 week after treatment.
RESULTSThe cure rate and the total effective rate were 58.3% and 96.7% respectively in the lactose-free formula group, and they were 8.3% and 85.0% respectively in the conventional formula group. There were significant differences in the therapeutic effect between the two groups (p<0.05). The duration of diarrhea remission (3.17+/-1.04 days) in the lactose-free formula group was significantly shorter than that in the conventional formula group (5.25+/-1.58 days) (p<0.05). After treatment the incidence of fecal flora disturbance was lower in the lactose-free formula group than that in the conventional formula group (p<0.05). No aderverse events were observed in the two groups.
CONCLUSIONSLactose-free formula feeding together with conventional therapy can significantly shorten the disease course and improve the treatment outcome in infants with acute diarrhea.
