Interleukin-4 and interleukin-13 concentrations in bronchoalveolar lavage fluid in neonates with respiratory distress syndrome and concurrent ventilator-associated pneumonia.
- Author:
Yao-Fang XIA
1
;
Cui-Qing LIU
;
Hui-Ju SHI
;
Li MA
Author Information
- Publication Type:Journal Article
- MeSH: Bronchoalveolar Lavage Fluid; immunology; Female; Humans; Infant, Newborn; Interleukin-13; analysis; Interleukin-4; analysis; Male; Microbial Sensitivity Tests; Pneumonia, Ventilator-Associated; immunology; microbiology; Respiratory Distress Syndrome, Adult; immunology
- From: Chinese Journal of Contemporary Pediatrics 2009;11(8):645-648
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the concentrations of IL-4 and IL-13 in bronchoalveolar lavage fluid (BALF) in neonates with respiratory distress syndrome (RDS) and concurrent ventilator-associated pneumonia (VAP).
METHODSSixty-eight neonates with RDS undergoing mechanical ventilation for over 48 hrs were enrolled. IL-4 and IL-13 levels in BALF were measured using ELISA 1, 72 and 96 hrs after mechanical ventilation. The results were compared between the neonates with concurrent VAP (n=37) and without (n=31).
RESULTSThe levels of BALF IL-4 96 hrs after ventilation in the VAP group (35.34+/-1.78 ng/mL) were significantly higher than those in the non-VAP group (13.69+/-2.47 ng/mL, P<0.05). The levels of BALF IL-13 96 hrs after ventilation in the VAP group (33.74+/-2.74 ng/mL) also increased significantly compared with those in the non-VAP group (13.50+/-3.81 ng/mL) (P<0.05). There were significant differences in BALF IL-4 and IL-13 levels between 1 hr and 96 hrs in the VAP group (P<0.05).
CONCLUSIONSBALF IL-4 and IL-13 levels increase in neonates with RDS and concurrent VAP. IL-4 and IL-13 may involve in the regulation of the inflammatory immune response.
