The in vitro effect of artesunate in the combination with primaquine or chloroquine on the hemolysis and oxygen uptake of human erythrocytes
- Author:
Mai Thi Chi Tran
- Publication Type:Journal Article
- Keywords:
Artesunate
- MeSH:
Artesunate;
primaquinel;
drug therapy;
Pharmaceutical Preparations;
erythrocytes
- From:Journal of Medical Research
2000;12(2):34-38
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The in vitro effect of artesunate in the combination with primaquine or chloroquine on the hemolysis and oxygen uptake of human erythrocytes was studied: 1. After exposure of human erythrocytes to artesunate at the concentrations from 1 to 10mM, the dose-dependent increase of hemolysis was observed. 2. At artesunate concentrations between 1 and 10mM, the increase of oxygen uptake in erythrocytes was seen. Primaquine, an oxidant drug, showed a synergistic effect with artesunate on hemolysis and oxygen uptake, while chloroquine was found to be antagonistic with artesunate on oxygen uptake. These findings indicate that artesunate exhibits oxidative effects.
