Research progress in fusion expression of antimicrobial peptides.
- Author:
Qingshan MA
1
;
Zhanqiao YU
;
Bing HAN
;
Rijun ZHANG
Author Information
1. Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100193, China.
- Publication Type:Journal Article
- MeSH:
Anti-Infective Agents;
metabolism;
Antimicrobial Cationic Peptides;
biosynthesis;
genetics;
Escherichia coli;
genetics;
metabolism;
Glutathione Transferase;
biosynthesis;
genetics;
Green Fluorescent Proteins;
biosynthesis;
genetics;
Recombinant Fusion Proteins;
biosynthesis;
genetics;
Thioredoxins;
biosynthesis;
genetics
- From:
Chinese Journal of Biotechnology
2011;27(10):1408-1416
- CountryChina
- Language:Chinese
-
Abstract:
Antimicrobial peptides (AMPs) are of great significance in the field of food, feed and medicine due to their wide spectrum of antimicrobial activity and new mechanism of action different from conventional antibiotics. AMPs production from natural sources is usually limited, and chemical synthesis is not economically practical, especially for the production of long peptides. Therefore, heterologous expression of AMPs has been widely studied as an alternative, and fusion expression plays an important role in increasing production. The present review mainly focuses on the types and bioactivities of AMPs. In addition, the recent strategies to the most commonly used carrier proteins for fusion expression of AMPs and prospects for future research were also discussed.
