Study on induction of ginsenosides on HL-60 cell apoptosis.
- Author:
Yang-ping NIU
1
;
Ruilan GAO
;
Tao HELEN
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; drug effects; Cell Division; drug effects; DNA, Neoplasm; analysis; Ginsenosides; pharmacology; HL-60 Cells; pathology; Humans
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(6):450-452
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe whether the Ginsenosides (GS) could induce HL-60 cell line apoptosis from promyelocytic leukemia.
METHODSHL-60 cells were treated with GS of various concentration to observe the effect of GS on cell morphological change, the DNA content change by flow cytometry, DNA ladder by electrophoresis, and apoptosis rate by Annexin V-FITC test of the cells.
RESULTSGS could inhibit the growth of HL-60 cells and induce cell apoptosis in a certain scope of dose and reacting time.
CONCLUSIONGS could specifically induce apoptosis in HL-60 cells, which provides an experimental basis for treatment of leukemia with GS as an supplemntary agent of chemotherapy.
