Effect of lugu Ganoderma lucidum on low-density lipoprotein oxidation and monocyte adhesion to endothelium.
- Author:
Hong-mei ZHANG
1
;
Wei-juan YAO
;
Hui-kai TIAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Adhesion; drug effects; Cells, Cultured; Drugs, Chinese Herbal; pharmacology; Endothelium, Vascular; cytology; Female; Glycation End Products, Advanced; metabolism; Humans; Lipoproteins, LDL; metabolism; Male; Monocytes; cytology; Oxidation-Reduction; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley; Reishi; Umbilical Veins; cytology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(7):534-537
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Lugu Ganoderma Lucidum (LGL) on low-density lipoprotein (LDL) oxidation and monocyte adhesion to endothelium (AdM-E) induced by oxydative LDL and advanced glycosylation endproducts (AGE) by using serum pharmacological technique.
METHODSLDL oxidation was determined by measuring the thiobarbituric acid reactive substances in the supernatants, and AdM-E was determined by measuring myeloperoxidase activity of adherent monocyte.
RESULTSSerum derived from rats 0.5 hrs, 1 hr, 2 hrs, 3 hrs after LGL administering 0.12 g/kg once and 0.5 hrs, 1 hr after LGL administering twice showed no significant effect on LDL oxidation, but the serum from rats 2 hrs, 3 hrs after LGL 0.12 g/kg administering twice or from rats after 10 successive days LGL administering in dose of 0.12 g/kg, 0.24 g/kg and 0.72 g/kg, all could lower the LDL oxidation (P < 0.05). Besides, the serum from rats with 10 days LGL administering of all dosages also could inhibit AdM-E induced by AGE (P < 0.05), and those of 0.24 g/kg and 0.72 g/kg could inhibit AdM-E induced by oxydative LDL (P < 0.05).
CONCLUSIONLGL could decrease LDL oxidation and AdM-E induced by AGE or oxydative LDL.
