The association study on infection of Mycobacterium leprae and RIPK2.
- Author:
Byoung Chul KIM
1
;
Tae Jin KANG
;
Gue Tae CHAE
Author Information
1. Institute of Hansen's disease, Department of Pathology, College of Medicine, The Catholic University of Korea, Korea.
- Publication Type:Original Article
- Keywords:
IFN-gamma;
IL-12;
Mycobacterium leprae;
RIPK2
- MeSH:
Animals;
Communicable Diseases;
Interleukin-12;
Interleukin-12 Subunit p40;
Interleukin-18;
Liver;
Lymph Nodes;
Mice;
Mycobacterium leprae*;
Mycobacterium*;
Phosphotransferases;
Signal Transduction;
Skin;
Spleen
- From:Korean Leprosy Bulletin
2003;36(2):23-29
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Receptor-interacting serine/threonine kinase 2(RIPK2) is an adaptor molecule involved in the signal pathway of TLRs. However, there is no report on association between RIPK2 expression and infectious disease including mycobacterial disease in which TLRs play main role on interaction of infection. We evaluated relationship between Mycobacterium leprae and RIPK 2 by real-time RT-PCR. This study revealed that RIPK2 expression was down-regulated in the footpads and skin but was up-regulated in the liver, lymph node, and spleen of Mycobacterium leprae-infected nu/nu mice compared with those of non-infected nu/nu mice. It was observed that the IL-12p40, IFN-gamma, and IL-18 involved in the susceptibility of Mycobacterium leprae were down-regulated in the skin and footpad but up-regulated in the liver. These results suggest that regulation of RIPK2 expression is tissue-specific and is associated with M. leprae infection.
