Effect of sappan wood on perforin mRNA expression in myocardium of rats after allogeneic cardiac transplantation.
- Author:
Ya-bin ZHOU
1
;
Feng-zhen YAO
;
Jia-rui HAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; pharmacology; Fabaceae; chemistry; Heart Transplantation; Male; Membrane Glycoproteins; biosynthesis; genetics; Myocardium; metabolism; pathology; Perforin; Pore Forming Cytotoxic Proteins; RNA, Messenger; biosynthesis; genetics; Rats; Rats, Sprague-Dawley; Rats, Wistar; Transplantation, Homologous
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(5):370-372
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Sappan wood (SW) on the expression of perforin mRNA in myocardium of rats after allogeneic cardiac transplantation.
METHODSThe animal model of allogeneic (abdominal) cardiac transplantation was established by taking Wistar rat as provider and SD rat as receptor, perforin mRNA expression in the model's myocardium was detected by RT-PCR.
RESULTSSW could obviously reduce the perforin mRNA expression, it also could alleviate the pathological morphology and ultrastructural damage of myocardial cells.
CONCLUSIONSW has obvious effect in antagonizing immune rejection after transplantation, the mechanism of its immunosuppression could be through lowering the perforin mRNA expression.
