Role of mitogen-activated protein kinase pathway in chloracne.
- Author:
Chun-mei ZHANG
1
;
Nai-jun TANG
;
Li DONG
;
Li-jun ZHAO
;
Shi-wei MA
;
Wen-guo WEI
;
Wan-qi ZHANG
;
Peng ZHANG
;
Wei HAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chloracne; metabolism; Humans; MAP Kinase Signaling System; physiology; Male; Middle Aged; Mitogen-Activated Protein Kinases; metabolism; Occupational Diseases; metabolism; Phosphorylation; physiology; Receptor, Epidermal Growth Factor; metabolism
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2008;26(3):154-156
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of mitogen-activated protein kinase (MAPK) signal transduction pathway in chloracne.
METHODSImmunohistochemical technique was used to detect the expression of phosphorylated epidermal growth factor receptor (p-EGFR) and p-MAPK proteins in the epithelium of chloracne group and control group.
RESULTSp-EGFR and p-MAPK was found in all chloracne tissues, whereas no expression of p-EGFR and p-MAPK protein was found in control group. In the skin of chloracne patients, p-EGFR was mainly distributed in the membrane and the cytoplasm, especially in the vicinity of membrane; major positive signal of p-MAPK was in core and serosity.
CONCLUSIONEGFR and MAPK phosphorylation is found in chloracne tissues. MAPK signal transduction pathway is one important molecular mechanism of chloracne.
