Association between apolipoprotein A1-75 bp gene polymorphisms and risk for dyslipidemia and coronary artery disease.
- Author:
Xuebiao WEI
1
;
Yaowang LIN
1
;
Xing YANG
1
;
Dan LIAN
1
;
Jiyan CHEN
1
;
Danqing YU
2
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alleles; Apolipoprotein A-I; genetics; Apolipoproteins B; Coronary Artery Disease; genetics; Coronary Disease; Diabetes Mellitus; Dyslipidemias; genetics; Female; Humans; Lipids; Male; Middle Aged; Mutation; Polymorphism, Genetic; Risk Factors; Smoking
- From: Chinese Journal of Cardiology 2014;42(11):916-921
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between the apolipoprotein ApoA1-75 bp polymorphism and risk for dyslipidemia and coronary artery disease (CAD).
METHODSA total of 723 patients (mean age (62.4 ± 10.2) years old) admitted to Guangdong General Hospital from 2011 to 2013 were enrolled. They were subdivided into CAD group (n = 444) and non-CAD (n = 279) group according to the result of coronary angiography (CAG). Clinical data including the profiles of lipids, -75 bp gene polymorphisms and Gensini scores were analyzed to determine the correlation between -75 bp gene polymorphisms, lipid profile and CAD.
RESULTFrequency of male gender, history of diabetes and smoking, TC, TG, LDL-C and ApoB level were significantly higher and HDL-C level was significantly lower in CAD group than in non-CAD group (all P < 0.05). Frequency of A allele was significantly lower in CAD group than in non-CAD group (43.7% (194/444) vs. 56.6% (158/279) , P = 0.003). The ApoA1-75 bp gene polymorphism was significantly correlated with CAD (P < 0.005). Multivariate logistic regression analysis showed that -75 bp gene polymorphism mutation (OR = 0.649, P = 0.021) is an independent protective factor for coronary heart disease.
CONCLUSIONApoA1-75 bp gene polymorphism is linked with risk of dyslipidemia and CAD.
