Association between apolipoprotein A1-75 bp gene polymorphisms and risk for dyslipidemia and coronary artery disease
10.3760/cma.j.issn.0253-3758.2014.11.009
- VernacularTitle:载脂蛋白A1-75bp位点多态性与血脂及冠状动脉病变程度的相关性
- Author:
Xuebiao WEI
1
;
Yaowang LIN
;
Xing YANG
;
Dan LIAN
;
Jiyan CHEN
;
Danqing YU
Author Information
1. 南方医科大学研究生学院
- Keywords:
Coronary disease;
Apolipoprotein A-Ⅰ;
Polymorphism,single nucleotide
- From:
Chinese Journal of Cardiology
2014;42(11):916-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the apolipoprotein ApoA1-75 bp polymorphism and risk for dyslipidemia and coronary artery disease (CAD).Methods A total of 723 patients (mean age (62.4 ± 10.2) years old) admitted to Guangdong General Hospital from 2011 to 2013 were enrolled.They were subdivided into CAD group (n =444) and non-CAD (n =279) group according to the result of coronary angiography (CAG).Clinical data including the profiles of lipids,-75 bp gene polymorphisms and Gensini scores were analyzed to determine the correlation between-75 bp gene polymorphisms,lipid profile and CAD.Result Frequency of male gender,history of diabetes and smoking,TC,TG,LDL-C and ApoB level were significantly higher and HDL-C level was significantly lower in CAD group than in non-CAD group (all P ＜ 0.05).Frequency of A allele was significantly lower in CAD group than in non-CAD group (43.7％ (194/444) vs.56.6％ (158/279),P =0.003).The ApoA1-75 bp gene polymorphism was significantly correlated with CAD (P ＜ 0.005).Multivariate logistic regression analysis showed that-75 bp gene polymorphism mutation (OR =0.649,P =0.021) is an independent protective factor for coronary heart disease.Conclusion ApoA1-75 bp gene polymorphism is linked with risk of dyslipidemia and CAD.
