Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma.
- Author:
Bei ZHANG
1
;
Siqi HAN
;
Bing FENG
;
Xiaoyuan CHU
;
Longbang CHEN
;
Rui WANG
Author Information
- Publication Type:Review
- MeSH: Carcinoma, Hepatocellular*; Cell Cycle Checkpoints; Cell Proliferation; Epigenomics; Genes, Tumor Suppressor; Hepatitis B virus*; Hepatitis B*; Hepatitis*; Humans*; MicroRNAs; Neoplasm Metastasis; Oncogenes; RNA, Long Noncoding; RNA, Untranslated*
- From:Experimental & Molecular Medicine 2017;49(2):e293-
- CountryRepublic of Korea
- Language:English
- Abstract: Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in HCC pathogens. Non-coding RNAs (ncRNAs) mainly include microRNAs and long non-coding RNAs (lncRNAs). Although ncRNAs cannot code proteins, growing evidence has shown that they have various important biological functions in cell proliferation, cell cycle control, anti-apoptosis, epithelial–mesenchymal transition, tumor invasion and metastasis. This review summarizes the current knowledge regarding the mechanisms and emerging roles of ncRNAs in the pathogenesis of HBV-related HCC. Accumulated data have shown that ncRNAs regulated by HBx have a crucial role in HBV-associated hepatocarcinogenesis. The findings of these studies will contribute to more clinical applications of HBV-related ncRNAs as potential diagnostic markers or as molecular therapeutic targets to prevent and treat HBV-related HCC.
