Experimental study on early escharectomy after major burns in minipigs.
- Author:
Gang XU
1
;
Chen-Wang DUAN
;
Shu-Qiang CHEN
;
Jun LIU
;
Feng-Shan LI
;
Yu-Zhu FENG
;
Dong-Mei LIU
;
Xiu-Hong DU
Author Information
- Publication Type:Journal Article
- MeSH: Acute-Phase Reaction; Animals; Atrial Function, Right; Burns; physiopathology; surgery; Cardiac Output; Cytokines; blood; Disease Models, Animal; Hemorheology; Swine; Swine, Miniature
- From: Chinese Journal of Burns 2005;21(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate optimal time for early escharectomy after severe scald in minipigs.
METHODSMinipigs inflicted with 35% TBSA full thickness burn were employed in the study, and they were randomly divided into A (n = 7, with escharectomy at 6PSH), and B (n = 7, with escharectomy at 24 PSH) groups. The hemodynamics indices, hemorrheology, and the serum levels of cytokines in the two groups were determined before burns and at 6, 8, 16, 24 and 72PSH.
RESULTSThe hemodynamics indices in A group obviously improved compared with those in B group. The cardiac output (CO, 2.28 +/- 0.03 L/min) and right arterial pressure (RAP, 4.54 +/- 0.04 mmHg) in A group recovered to the pre-injury levels at 48 PSH. There was no difference of the hemorrheology indices between the two groups (P > 0.05). The serum contents of cytokines in A group declined to the pre-injury level on 1 PBW, while those in B group were significantly higher than those before injury and those in A group (P < 0.05 or P > 0.01).
CONCLUSIONEscharectomy during 6 PBH might be safe and feasible, thus preventing long-term complications effectively.
