Cytotoxicity of the rhizome of medicinal plants.
- Author:
Shakhawoat HOSSAIN
1
;
Golam KADER
;
Farjana NIKKON
;
Tanzima YEASMIN
Author Information
- Publication Type:Journal Article
- Keywords: Bangladesh; Curcuma zedoaria; Cytotoxicity; Zingiber zerumbet
- MeSH: Animals; Artemia; drug effects; Curcuma; metabolism; toxicity; Phytotherapy; Plant Extracts; pharmacology; toxicity; Plants, Medicinal; toxicity; Rhizome; toxicity; Zingiberaceae; metabolism; toxicity
- From:Asian Pacific Journal of Tropical Biomedicine 2012;2(2):125-127
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the cytotoxicity of the crude ethanol extract of the rhizome of Zingiber zerumbet (Z. zerumbet) (L) Smith. and Curcuma zedoaria (C. zedoaria) Rosc. against Artemia salina Leach.
METHODSFresh rhizomes of Z. zerumbet (L) Smith. and C. zedoaria Rosc. were extracted separately in cold with ethanol (2.5 L) and after concentration a brownish syrupy suspension of ethanol extracts of Z. zerumbet (L) Smith. and C. zedoaria Rosc. was obtained. The cytotoxic effect of the crude ethanol extracts of both plants was determined by brine shrimp lethality bioassay.
RESULTSCrude ethanol extracts of the rhizome of Z. zerumbet (L) Smith. showed the highest cytotoxicity (LC50 was 1.24 µg/mL) against brine shrimp nauplii as compared with C. zedoaria Rosc. (LC50 was 33.593 µg/mL) after 24 h of exposure.
CONCLUSIONSIt can be concluded that the rhizome of Z. zerumbet (L) Smith. and C. zedoaria Rosc. can be used as a source of cytotoxic agent.
