Anti-inflammatory and analgesic activities of Melanthera scandens.
- Author:
Jude E OKOKON
1
;
Anwanga E UDOH
;
Samuel G FRANK
;
Louis U AMAZU
Author Information
- Publication Type:Journal Article
- Keywords: Analgesic; Anti-inflammatory; Melanthera scandens
- MeSH: Acetic Acid; toxicity; Albumins; adverse effects; Analgesics; therapeutic use; Animals; Anti-Inflammatory Agents; therapeutic use; Asteraceae; metabolism; Carrageenan; toxicity; Edema; drug therapy; Formaldehyde; toxicity; Inflammation; chemically induced; drug therapy; Mice; Pain; chemically induced; drug therapy; Phytochemicals; therapeutic use; Phytotherapy; Plant Extracts; therapeutic use; Plant Leaves; metabolism
- From:Asian Pacific Journal of Tropical Biomedicine 2012;2(2):144-148
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the anti-inflammatory and analgesic activities of leaf extract of Melanthera scandens (M. scandens).
METHODSThe crude leaf extract (39-111 mg/kg) of M. scandens was investigated for anti-inflammatory and analgesic activities using various experimental models. The anti-inflammatory activity was investigated using carragenin, egg-albumin induced oedema models, while acetic acid, formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property.
RESULTSThe extract caused a significant (P<0.05 - 0.001) dose-dependent reduction of inflammation and pains induced by different agents used.
CONCLUSIONSThe leaf extract possesses anti-inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant.
