Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines.
- Author:
Soundararajan VIJAYARATHNA
1
;
Sreenivasan SASIDHARAN
Author Information
- Publication Type:Journal Article
- Keywords: Cell morphology; Cytotoxicity; Elaeis guineensis; Growth inhibitory
- MeSH: Animals; Antineoplastic Agents, Phytogenic; pharmacology; Arecaceae; chemistry; Cell Proliferation; drug effects; Cercopithecus aethiops; Dose-Response Relationship, Drug; Humans; MCF-7 Cells; Methanol; Plant Extracts; pharmacology; toxicity; Plant Leaves; chemistry; Vero Cells
- From:Asian Pacific Journal of Tropical Biomedicine 2012;2(10):826-829
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7 and Vero cell.
METHODSIn vitro cytotoxicity was evaluated in by MTT assay. Cell morphological changes were observed by using light microscope.
RESULTSThe MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on MCF-7. Morphological alteration of the cell lines after exposure with Elaeis guineensis extract were observed under phase contrast microscope in the dose dependent manner.
CONCLUSIONSThe results suggest the probable use of the Elaeis guineensis methanol extract in preparing recipes for cancer-related ailments. Further studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.
