Clinical and pathologic analysis of astrocytic tumors with loss of heterozygosity on chromosome 10q.
- Author:
Fu-an ZHOU
1
;
Jun-zhi LI
;
Yu-qing MA
;
Na MIAO
;
Xia LIU
;
Xin-xia LI
;
Wei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Age Factors; Astrocytoma; genetics; pathology; surgery; Brain Neoplasms; genetics; pathology; surgery; Child; Chromosomes, Human, Pair 10; genetics; Female; Follow-Up Studies; Glioblastoma; genetics; pathology; surgery; Humans; Loss of Heterozygosity; Male; Middle Aged; Neoplasm Grading; Survival Rate; Young Adult
- From: Chinese Journal of Pathology 2012;41(9):618-621
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the correlation between loss of heterozygosity (LOH) on chromosome 10q and pathologic features, pathogenesis, prognosis of astrocytic tumors.
METHODSLOH on 10q was studied by interphase fluorescence in-situ hybridization (FISH) in 85 cases of astrocytic tumor, including 35 cases of WHO grade II tumors and 50 cases of WHO grade IV tumors.
RESULTSLOH on 10q was detected in 6 cases (17.1%) of diffuse astrocytoma (WHO grade II) and 34 cases (68.0%) of glioblastoma (WHO grade IV). 10q polysomy was detected in 7 cases (20.0%) of diffuse astrocytoma and 11 cases (22.0%) of glioblastoma. The rates of LOH on 10q in young age group and elderly group were 36.4% (12/33) and 82.4% (28/34), respectively. The difference was of statistical significance (P < 0.05). The rates of LOH on 10q in the diffuse astrocytoma and glioblastoma were 21.4% (6/28) and 87.2% (34/39), respectively. The difference was also statistically significant (P < 0.05). Univariate survival analysis showed that patient age, pathologic grade and 10q on LOH correlated with duration of survival (P < 0.05).
CONCLUSIONSThere are correlation between 10q LOH, patient age and pathologic grade of astrocytic tumors. LOH on 10q is also related to the pathogenesis of astrocytic tumors and is helpful in predicting prognosis.
