Gene expression of epidermal growth factor and epidermal growth factor receptor in oral lichen planus.
- Author:
Jie FU
1
;
Wei CHEN
;
Zheng SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Epidermal Growth Factor; metabolism; Humans; Lichen Planus, Oral; metabolism; pathology; Middle Aged; Mouth Mucosa; metabolism; pathology; Proto-Oncogene Proteins c-fos; metabolism; Proto-Oncogene Proteins c-jun; metabolism; RNA, Messenger; metabolism; Receptor, Epidermal Growth Factor; metabolism
- From: Chinese Journal of Stomatology 2005;40(6):455-458
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of epidermal growth factor (EGF), epidermal growth factor receptor (EGFR), c-fos and c-jun in oral lichen planus (OLP).
METHODSThe levels of gene expression of EGF, EGFR, c-fos and c-jun were detected with reverse transcription-polymerase chain reaction (RT-PCR) in 10 cases of erosive OLP, 12 cases of reticular OLP and 9 cases of normal oral mucosa. Protein contents and distribution of EGF, EGFR, C-fos and C-jun were examined with immunohistochemical technique in different tissues.
RESULTSThe endogenous levels of EGFR mRNA and protein in erosive OLP were (55.9 +/- 23.1)% and (71.1 +/- 10.1)%, respectively, and significantly higher than those in reticular OLP and normal oral mucosa. The mRNA contents of c-fos and c-jun were significantly higher in erosive OLP than in normal oral mucosa. The positive cell rates of c-fos and c-jun protein in erosive OLP were 1.3 and 1.5 times of those in normal oral mucosa, respectively (P < 0.05).
CONCLUSIONSThe probability of carcinomatous change of erosive OLP might be higher than that of reticular OLP, in which EGF and EGFR might play an important role.
