Expression and significance of macrophage migration inhibitory factor in bladder urothelial cell carcinoma.
- Author:
Yong-Shun GUO
1
;
Yu-Ping DAI
;
Wen LI
;
Lu-Dong LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Carcinoma, Transitional Cell; metabolism; pathology; surgery; Cystectomy; methods; Disease-Free Survival; Female; Follow-Up Studies; Humans; Intramolecular Oxidoreductases; metabolism; Kaplan-Meier Estimate; Macrophage Migration-Inhibitory Factors; metabolism; Male; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Urinary Bladder; metabolism; pathology; Urinary Bladder Neoplasms; metabolism; pathology; surgery
- From: Chinese Journal of Oncology 2011;33(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the expression and clinical significance of macrophage migration inhibitory factor (MIF) in patients with bladder urothelial cell carcinoma.
METHODSImmunohistochemical staining for MIF was performed on tissue sections of 110 patients with bladder urothelial cell carcinoma and 10 normal controls, and the correlations between MIF and clinicopathological characteristics and prognosis were also analyzed.
RESULTSNormal bladder urothelium from control subjects showed negative or weak staining of MIF. Of the cancer specimens, 72/110 (65.5%) showed a moderate to strong staining of MIF. The expression of MIF protein was found predominantly in the tumor cell cytoplasm and inversely correlated with tumor stage. 27 cases also showed a positive intranuclear staining of MIF, which was inversely correlated with tumor grade, stage and tumor size. Kaplan-Meier analysis showed that the expression of MIF in the cell nuclei was associated with disease-free survival for the cancer patients, but multivariate analysis showed that MIF was not an independent prognostic factors.
CONCLUSIONSThe expression of MIF in non-muscle invasive bladder cancer tissues was more frequently than that in muscle-invasive disease, the positive staining of MIF in cell nuclei might be a favorable biomarker for patients with bladder urothelial cell carcinoma.
