Diagnostic value of serum angiopoietin-2 level in pancreatic cancer.
- Author:
Ru-Gen WAN
1
;
De-Bao CHEN
;
Yong-Gang LOU
;
Mao-Feng WANG
;
Qiao-Hong ZHANG
;
Dan-Xia JIN
;
Sun-Hong ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Angiopoietin-2; blood; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Pancreatic Neoplasms; blood; diagnosis; pathology; Pancreatitis; blood; ROC Curve; Retrospective Studies
- From: Chinese Journal of Oncology 2011;33(1):47-49
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the diagnostic value of serum angiopoietin-2 (Ang-2) level in pancreatic cancer patients.
METHODSSerum Ang-2 level was measured by enzyme-linked immunosorbent assays (ELISA) in samples from 116 patients with pancreatic cancer, 50 patients with chronic pancreatitis, and 50 normal control subjects.
RESULTSThe serum Ang-2 level in patients with pancreatic cancer [(1539.0 ± 449.3) ng/L] was significantly higher than those in patients with pancreatitis [(1044.6 ± 246.1) ng/L, P < 0.01] and normal control subjects [(1075.6 ± 228.2) ng/L, P < 0.01]. There was no significant difference of serum Ang-2 levels between patients with pancreatitis and normal controls. Pancreatic caner patients with lymph node metastasis had a significantly higher serum Ang-2 level [(1890.1 ± 354.9) ng/L] than those without metastasis [(1212.1 ± 224.2) ng/L, P < 0.01]. The area under ROC curve of serum Ang-2 level for diagnosis of pancreatic cancer was 0.819.
CONCLUSIONThe serum Ang-2 level can be a useful indicator for diagnosis of pancreatic cancer.
