Nedaplatin or cisplatin combined with 5-fluorouracil for treatment of stage III-IVa nasopharyngeal carcinoma: a randomized controlled study.
- Author:
Ka-Jia CAO
1
;
Ai-Lan ZHANG
;
Wen-Juan MA
;
Pei-Yu HUANG
;
Dong-Hua LUO
;
Wei-Xiong XIA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Cisplatin; adverse effects; therapeutic use; Female; Fluorouracil; administration & dosage; adverse effects; therapeutic use; Humans; Lymphatic Metastasis; Male; Middle Aged; Nasopharyngeal Neoplasms; drug therapy; pathology; Nausea; chemically induced; Neoplasm Staging; Organoplatinum Compounds; administration & dosage; adverse effects; Remission Induction; Vomiting; chemically induced
- From: Chinese Journal of Oncology 2011;33(1):50-52
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the efficacy and side effects of nedaplatin plus 5-fluorouracil (5-Fu) and cisplatin plus 5-Fu for treatment of stage III-IVa nasopharyngeal carcinoma (NPC).
METHODSA total of 100 patients with NPC proved by histopathology were divided into nedaplatin plus 5-Fu group (NF group) and cisplatin plus 5-Fu group (PF group), 50 cases in each group. NF group: nedaplatin 30 mg/m(2), d1-d3, 5-Fu 500 mg/m(2) d1-d5, repeated every 3 weeks for 2 cycles. PF group: cisplatin 30 mg/m(2) d1-d3, 5-Fu 500 mg/m(2) d1-d5, repeated every 3 weeks for 2 cycles. χ(2) test was used to compare the efficacy and side-effects of the two groups.
RESULTSAll the 100 cases were evaluable and their clinical data in the two groups were comparable. Six patients with complete response were observed, 3 cases in NF group and 3 in PF group. The overall response rates were 86.0% in NF group and 84.0% in PF group, with no significant difference (χ(2) = 0.078, P = 0.779). The rates of leukocytopenia, thrombocytopenia, impairment of hepatic and renal function were similar whereas more patients in the PF group than in the NF group suffered from nausea and vomiting (88.0% vs. 56.0%, P = 0.000).
CONCLUSIONSNedaplatin plus 5-Fu is an effective treatment regimen for NPC. When compared with PF regimen, the response rate is similar. However, NF regimen shows a significant superiority in reducing nausea and vomiting.
