Effecacy of three-dimensional conformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma.
- Author:
Xin-hong LIU
1
;
Wei-lu LI
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; drug therapy; radiotherapy; surgery; Adult; Aged; Antimetabolites, Antineoplastic; adverse effects; therapeutic use; Combined Modality Therapy; Diarrhea; etiology; Exanthema; chemically induced; etiology; Female; Humans; Leukopenia; etiology; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Period; Quality of Life; Radiotherapy, Conformal; adverse effects; Rectal Neoplasms; drug therapy; radiotherapy; surgery; Remission Induction; Survival Rate; Tegafur; adverse effects; therapeutic use
- From: Chinese Journal of Oncology 2011;33(4):299-301
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the local control rate, survival time and side effect of three-dimensional conformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma.
METHODSForty patients with postoperative recurrent rectal carcinoma received three-dimensional conformal radiation therapy, 1.8 - 2.0 Gy/once, 5 times every week and the total dose was 54 - 65 Gy. At the same time, the patients took Tegafur orally 40 mg/m(2) twice per day for consecutive 28 days, and one cycle lasted for 42 days. The chemotherapy was applied for 2 cycles after radiotherapy.
RESULTSThe total effective rate (CR + PR) was 70.0%, improvement rate was 90.0%, 1-year survival rate was 70.0%, and 1-year local control rate was 62.5%. There was only a little side effect.
CONCLUSIONSThree-dimensional conformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma have definite effect, with a high local control rate, and patients well tolerance the treatment without serious side effect. It can apparently improve the life quality of the patients.
