Weekly regimen of paclitaxel liposome combined with cisplatin and 5-fluorouracil continuous infusion in the treatment of advanced gastric carcinoma.
- Author:
Jian-huang LI
1
;
Bin LI
;
Hai-rong JIANG
;
Mei-zuo ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; drug therapy; pathology; secondary; surgery; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; administration & dosage; adverse effects; therapeutic use; Cisplatin; administration & dosage; Female; Fluorouracil; administration & dosage; Follow-Up Studies; Humans; Infusions, Intravenous; Leukopenia; chemically induced; Liposomes; Liver Neoplasms; drug therapy; secondary; Male; Middle Aged; Nausea; chemically induced; Neoplasm Staging; Paclitaxel; administration & dosage; adverse effects; Remission Induction; Stomach Neoplasms; drug therapy; pathology; surgery; Survival Rate; Vomiting; chemically induced; Young Adult
- From: Chinese Journal of Oncology 2011;33(3):229-231
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and toxicity of paclitaxel with low-dose cisplatin and 5-fluorouracil continuous infusion in the treatment of advanced gastric carcinoma.
METHODSThe patients were treated with paclitaxel liposome 60 mg/m(2) i.v. gtt on d1, 8, 15, DDP 15 mg×m(-2)×d(-1) by i.v. gtt on d1-5, 5-Fu 500 mg×m(-2)×d(-1) by civ for 120 h, administered every 21 days.
RESULTSOut of the whole group, 3 cases achieved CR, 29 cases achieved PR with an ORR of 54.2% and median TTP of 7.1 months. Out of 40 cases in the primary treatment, 3 cases achieved CR, 22 cases achieved PR with an ORR of 62.5% and median TTP of 7.6 months. Out of 20 evaluable retreated cases, no case achieved CR, 7 cases achieved PR with an ORR of 36.8% and median TTP 6.3 months. The main toxicities were hematological toxicities, nausea and vomiting of grade I-II.
CONCLUSIONThe combination regimen of paclitaxel, low-dose cisplatin and 5-fluorouracil is effective and well tolerated for patients with advanced gastric carcinoma, especially for primary treatment cases. It is worthy of further study.
