Efficacy and side effects of combination therapy of oxaliplatin and S-1 for colorectal cancer.
- Author:
Qing-chao ZHU
1
;
Zhi-ming JIN
Author Information
- Publication Type:Clinical Trial
- MeSH: Adenocarcinoma; drug therapy; surgery; Adenocarcinoma, Mucinous; drug therapy; surgery; Aged; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Colonic Neoplasms; drug therapy; surgery; Diarrhea; chemically induced; Female; Humans; Leukopenia; chemically induced; Male; Middle Aged; Organoplatinum Compounds; administration & dosage; adverse effects; Oxonic Acid; administration & dosage; adverse effects; Postoperative Period; Pyridines; administration & dosage; adverse effects; Rectal Neoplasms; drug therapy; surgery; Remission Induction; Tegafur; administration & dosage; adverse effects; Vomiting; chemically induced
- From: Chinese Journal of Oncology 2011;33(5):388-390
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the efficacy and side effects of the combination therapy of oxaliplatin and S-1 in treating postoperative colorectal cancer patients.
METHODS54 postoperative colorectal cancer patients received the combination therapy of oxaliplatin and S-1 regimen, repeated every 3 weeks, and evaluate the efficacy after 3 cycles.
RESULTSAll of the 54 patients but 2 (changed the chemotherapy regimen after the first cycle because of economic reason) finished 6 cycles of the chemotherapy treatment. There were 6 cases (11.5%) with complete response (CR), 28 cases (53.8%) with partial response (PR), and the overall response rate was 65.4%. Major adverse effects were hematological toxicities, gastrointestinal disturbance, neurosensory toxicity. There were no chemotherapy-related deaths.
CONCLUSIONSOxaliplatin combined with S-1 is an effective and better tolerated chemotherapy treatment for postoperative colorectal cancer patients, with no serious side effects for liver and kidney. Therefore, it can be used as an alternative chemotherapy regimen for postoperative colorectal cancer patients.
