Short-term intermittent prophylactic administration of recombinant human thrombopoietin attenuates chemotherapy-induced thrombocytopenia in lung cancer patients.
- Author:
Yun-hua XU
1
;
Bai-jun CHENG
;
Shun LU
;
Hong JIAN
;
Zhen ZHOU
;
Zhi-wei CHEN
;
Xiang-yun YE
Author Information
- Publication Type:Clinical Trial
- MeSH: Adenocarcinoma; blood; drug therapy; pathology; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Area Under Curve; Carboplatin; administration & dosage; adverse effects; Cisplatin; administration & dosage; adverse effects; Deoxycytidine; administration & dosage; adverse effects; analogs & derivatives; Dizziness; chemically induced; Female; Fever; chemically induced; Humans; Lung Neoplasms; blood; drug therapy; pathology; Male; Middle Aged; Neoplasm Staging; Platelet Count; Recombinant Proteins; adverse effects; therapeutic use; Thrombocytopenia; blood; chemically induced; drug therapy; Thrombopoietin; adverse effects; therapeutic use
- From: Chinese Journal of Oncology 2011;33(5):395-399
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of short-term intermittent prophylactic use of a recombinant human thrombopoietin (rhTPO) in chemotherapy-induced severe thrombocytopenia in lung cancer patients.
METHODS24 advanced non-small cell lung cancer (NSCLC) patients who experienced severe thrombocytopenia in the last chemotherapy cycle received prophylactic rhTPO treatment in the next chemotherapy cycle (prophylactic treated cycle, PTC). rhTPO was given subcutaneously 300 U×kg(-1)×d(-1) on days 2, 4, 6, and 9 after the initiation of chemotherapy. Platelet count was monitored and compared with that in the previous treatment cycle (control cycle, CC).
RESULTSThe lowest platelet count in the prophylactic rhTPO cycle was significantly higher than that in control cycle [(56 ± 16) × 10(9)/L vs. (28 ± 13) × 10(9)/L, P < 0.001]. The duration of thrombocytopenia was also shortened by the prophylactic rhTPO [(8 ± 2) d vs. (12 ± 3) d, P < 0.001]. The area under curve (AUC) of platelet count (21 days) was significantly increased [(3517 ± 685) × 10(9)/L vs. (2063 ± 436) × 10(9)/L, P < 0.001]. The time to platelet nadir and peak was not affected.
CONCLUSIONProphylactic use of rhTPO can attenuate the severity and shorten the duration of chemotherapy-induced thrombocytopenia in lung cancer patients.
