Elevated Plasma Pentraxin 3 and Its Association with Retinal Vein Occlusion.
10.3341/kjo.2014.28.6.460
- Author:
Kyung Soo PARK
1
;
Ji Wan KIM
;
Jae Hwan AN
;
Je Moon WOO
Author Information
1. Department of Ophthalmology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. limbus68@naver.com
- Publication Type:Original Article
- Keywords:
Biological markers;
Inflammation;
Ischemia;
Pentraxin3;
Retinal vein occlusion
- MeSH:
Acute-Phase Proteins/metabolism;
Adult;
Aged;
Aged, 80 and over;
Biomarkers/*blood;
C-Reactive Protein/*metabolism;
Case-Control Studies;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Male;
Middle Aged;
Retinal Vein Occlusion/*blood/diagnosis;
Serum Amyloid P-Component/*metabolism
- From:Korean Journal of Ophthalmology
2014;28(6):460-465
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate plasma pentraxin 3 (PTX3) in patients with retinal vein occlusion (RVO), and investigate the possibility of its role as a predictive biomarker. METHODS: Nested case-control study. The study included 57 patients with RVO and 45 age- and gender-matched subjects without RVO as controls. Plasma PTX3 and C-reactive protein concentration were measured in both groups a posteriori from frozen samples by using an enzyme-linked immunosorbent assay kit. RESULTS: The measured PTX3 value for the RVO group was 1,508 +/- 1,183 pg/mL (mean +/- standard deviation) and 833 +/- 422 pg/mL for the controls (p < 0.001). There was no significant difference in PTX3 levels between patients with central retinal vein occlusion and branched retinal vein occlusion (1,468 +/- 1,300 vs. 1,533 +/- 1,121 pg/mL; p = 0.818). CONCLUSIONS: Our data seems to support the role of chronic inflammation and ischemia in the development of RVO. It is possible that PTX3 can be used as a diagnostic biomarker of RVO.
