Congenital Aniridia: Long-term Clinical Course, Visual Outcome, and Prognostic Factors.
10.3341/kjo.2014.28.6.479
- Author:
Ji Woong CHANG
1
;
Jeong Hun KIM
;
Seong Joon KIM
;
Young Suk YU
Author Information
1. Department of Ophthalmology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Aniridia;
Eye abnormalities;
Prognosis
- MeSH:
Adolescent;
Adult;
Aniridia/*diagnosis/physiopathology;
Cataract/diagnosis;
Child;
Child, Preschool;
Corneal Diseases/diagnosis;
Eye Abnormalities/diagnosis;
Eye Diseases/*diagnosis/physiopathology;
Follow-Up Studies;
Humans;
Infant;
Infant, Newborn;
Nystagmus, Pathologic/diagnosis;
Ocular Hypertension/diagnosis;
Prognosis;
Retina/abnormalities;
Retrospective Studies;
Visual Acuity/*physiology;
Young Adult
- From:Korean Journal of Ophthalmology
2014;28(6):479-485
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To describe the clinical course of congenital aniridia and to evaluate prognostic factors for visual outcome after long-term follow-up. METHODS: The medical records of 120 eyes from 60 patients with congenital aniridia were retrospectively reviewed. The prevalence and clinical course of ophthalmic characteristics, systemic disease, refractive errors, and visual acuity were assessed. Prognostic factors for final visual outcomes were analyzed. RESULTS: Aniridic keratopathy developed in 82 (69%) of 119 eyes. Macular hypoplasia was observed in 70 eyes of 35 patients (91%). Cataract was observed in 63 of 120 eyes (53%). Nystagmus was present in 41 patients (68% of 60 patients) at the initial visit but decreased in five patients (8% of 60 patients). Ocular hypertension was detected in 19 eyes (20% of 93 eyes), six (32% of 19 eyes) of which developed secondarily after cataract surgery. The mean changes in spherical equivalent and astigmatism during the follow-up period were -1.10 and 1.53 diopter, respectively. The mean final visual acuity was 1.028 logarithm of minimal angle of resolution. Nystagmus and ocular hypertension were identified as prognostic factors for poor visual outcome. CONCLUSIONS: Identification of nystagmus and ocular hypertension was important to predict final visual outcome. Based on the high rate of secondary ocular hypertension after cataract surgery, careful management is needed.
