Association of Lipoprotein-Associated Phospholipase A2 with Characteristics of Vulnerable Coronary Atherosclerotic Plaques.
10.3349/ymj.2011.52.6.914
- Author:
Yu Sheng LIU
1
;
Xiao Bo HU
;
Hong Zhuan LI
;
Wei Dong JIANG
;
Xin WANG
;
Hao LIN
;
Ai Qiong QIN
;
Yong Mei WANG
;
Tong ZHAO
;
Zhao Qiang DONG
;
Mei ZHANG
;
Qing Hua LU
Author Information
1. Department of Cardiology, The Qilu Hospital of Shandong University, Jinan, China. daixh@vip.sina.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Vulnerable plaque;
lipoprotein-associated phospholipase A2;
atherosclerosis
- MeSH:
1-Alkyl-2-acetylglycerophosphocholine Esterase/*blood;
Adult;
Aged;
Aged, 80 and over;
Angina, Stable/*blood/enzymology/*pathology;
Angina, Unstable/*blood/enzymology/pathology;
Coronary Angiography;
Coronary Artery Disease/*blood/enzymology/*pathology;
Female;
Humans;
Male;
Middle Aged
- From:Yonsei Medical Journal
2011;52(6):914-922
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory enzyme expressed in atherosclerotic plaques. We investigated the association of circulating Lp-PLA2 with characteristics of vulnerable coronary atherosclerotic plaques. MATERIALS AND METHODS: We recruited 113 patients with either unstable angina (UA, n=59) and stable angina (SA, n=54) by coronary angiography. Thirty-six healthy subjects served as controls. Intravascular ultrasound (IVUS) was used to evaluate the characteristics of coronary atherosclerotic plaque, and serum Lp-PLA2 concentration was measured as well. RESULTS: Lp-PLA2 concentration was significantly higher in both UA and SA patients [(396+/-36) microg/L and (321+/-39) microg/L, respectively] compared with the controls [(127+/-49) microg/L, p<0.01], and higher in UA than SA group. IVUS findings showed that remodeling index (RI) (0.91+/-0.15 vs. 0.85+/-0.11, p=0.005) and eccentricity index (EI) (0.73+/-0.16 vs. 0.65+/-0.22, p=0.039) were larger in UA than in SA group, and fibrous caps were thicker in SA than UA group [(0.91+/-0.23) mm vs. (0.63+/-0.21) mm, p=0.032]. Moreover, Lp-PLA2 correlated positively with EI (r=0.439, p<0.01) and RI (r=0.592, p<0.05) in UA group. There was an inverse relationship between Lp-PLA2 and fibrous cap thickness in both UA (r=-0.587, p<0.001) and SA (r=-0.318, p<0.05) groups. The independent risk factors in UA group were Lp-PLA2 (OR=1.055, 95% CI: 1.03-1.08, p=0.013), LDL-cholesterol (OR=0.032, 95% CI: 0.00-0.05, p=0.041) and fibrous cap thickness (OR=0.008, 95% CI: 0.00-0.45, p=0.019). Lp-PLA2 was strongly associated with both EI and fibrous cap thickness in both groups. CONCLUSION: Serum level of Lp-PLA2 is associated with both eccentricity index and fibrous cap thickness in both UA and SA groups. Elevated levels of circulating Lp-PLA2 might to be a strong risk factor and more serious for unstable angina than stable angina.
