Clinical analysis of 49 cases of esthesioneuroblastoma
10.3760/cma.j.issn.1673-0860.2014.03.008
- VernacularTitle:嗅神经母细胞瘤49例临床分析
- Author:
Mingfeng MAO
1
;
Rongguang WANG
;
Hongtian WANG
;
Xinxin ZHANG
;
Lei CHEN
Author Information
1. 100853北京,解放军总医院耳鼻咽喉头颈外科
- Keywords:
Esthesioneuroblastoma,olfactory;
Nose neoplasms;
Nasal cavity;
Combined modality therapy;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2014;49(3):210-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the optimal treatment and prognostic factors of esthesioneuroblastoma(ENB).Method Forty-nine cases of ENB,received therapies in Chinese people liberation army general hospital from October 2004 to June 2013,were reviewed retrospectively.The therapeutical strategies and prognostic factors were analyzed using the Kaplan-Meier method.Efficacy of different therapeutical strategies was compared.Result The 5-year overall survival(OS) in the group was 63.8％.The 5-year OS of Kadish stage A,B,C were 90.0％,77.1％,32.6％,respectively,with significant difference (x2 =7.379,P =0.03).The 5-year OS of the patients treated by surgery and radiotherapy,chemoradiotherapy,surgery with chemoradiotherapy were 68.6％,0,92.3％,respectively,with significant difference (x2 =8.140,P =0.02).The 5-year OS of the patients with transnasal endoscopic resection (or combined with transcranial resection) and lateral rhinotomy (or combined with transcranial resection) were 63.7％,50.0％,respectively,which had no significant difference (x2 =3.818,P =0.05).Conclusions ENB has a relatively good prognosis in head and neck malignancies,the prognosis is associated with clinical stages and treatment approaches.Transnasal endoscopic surgery based multimodality is the preferable choice.
