The Association of SERPINE2 Gene with COPD in a Chinese Han Population.
10.3349/ymj.2011.52.6.953
- Author:
Aihua WANG
1
;
Yingqiu YIN
;
Ping CHEN
;
Qiji LIU
;
Qinfeng YU
;
Wei XIAO
Author Information
1. Department of Respiratory, Qilu Hospital of Shandong University, Shandong, China. Xiaowei4226@163.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Chronic obstructive pulmonary disease;
SERPINE2 gene;
polymorphism;
susceptibility
- MeSH:
Asian Continental Ancestry Group;
Case-Control Studies;
Female;
Genetic Predisposition to Disease/genetics;
Genotype;
Haplotypes/genetics;
Humans;
Male;
Middle Aged;
Polymorphism, Restriction Fragment Length/genetics;
Polymorphism, Single Nucleotide/genetics;
Pulmonary Disease, Chronic Obstructive/*genetics;
Serpin E2/*genetics
- From:Yonsei Medical Journal
2011;52(6):953-960
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Polymorphisms of several candidate genes have been studied and associated with the development of chronic obstructive pulmonary disease (COPD). One such candidate is the SERPINE2 (Serpin peptidase inhibitor, clade E member 2) gene. MATERIALS AND METHODS: To assess whether the SERPINE2 gene is associated with COPD in a Chinese Han population. Samples were collected from a Chinese Han population and analyzed for the association of single nucleotide polymor phisms (SNPs) or haplotypes of SERPINE2 gene with COPD in a case-control study. Three SNPs including rs840088 G/A in intron 1, rs1438831 A/G in 5' upstream sequence and rs3795879 G/A in intron 3 were detected using the polymerase chain reaction (PCR)-based restriction fragment length polymorphism technique in 409 COPD subjects and 411 controls. Genotyping of the SREPINE2 polymorphisms at positions rs840088, rs1438831and rs3795879 was performed. RESULTS: We found that none of the rs840088G/A, rs1438831G/A and rs3795879 G/A polymorphisms were associated with the disease. The p-values were 0.630, 0.208 and 0.398 respectively. CONCLUSION: Our data suggested that there was no significant association between SERPINE2 polymorphism and COPD susceptibility in the Chinese Han population.
