Structural modification and bioactivity of cyclovirobuxine D.
- Author:
Lan DENG
1
;
Heng HUANG
;
Ming-xia XU
;
Shi-qing ZHOU
;
Xing-wen WANG
;
Miao LU
;
Fang REN
;
Dai-qing LI
Author Information
- Publication Type:Journal Article
- MeSH: Anaerobic Threshold; drug effects; Animals; Anti-Arrhythmia Agents; chemical synthesis; pharmacology; Buxus; chemistry; Chloroform; Drugs, Chinese Herbal; chemical synthesis; isolation & purification; pharmacology; Female; Male; Mice; Molecular Structure; Plants, Medicinal; chemistry; Random Allocation; Ventricular Fibrillation; chemically induced; prevention & control
- From: Acta Pharmaceutica Sinica 2004;39(6):434-438
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo search for new compounds for the treatment of cardiovascular diseases by structural modification of cyclovirobuxine D.
METHODSAccording to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.
RESULTSTen new compounds were syntheized and confirmed by spectra.
CONCLUSIONEndurance lacking oxygen activity and antiarrhythmia effects of some analogues of cyclovirobuxine D were tested. Some compounds showed better activity than cyclovirobuxine D.
