Studies on combined release behaviors of versatile mini-tablets in capsule systems and fittings of their mathematical model.
- Author:
Ying-huan LI
1
;
Jia-bi ZHU
;
Sheng-jun CHEN
;
Ying-jun JIA
Author Information
- Publication Type:Journal Article
- MeSH: Capsules; Delayed-Action Preparations; Drug Delivery Systems; Models, Chemical; Nifedipine; administration & dosage; chemistry; Polyethylene Glycols; administration & dosage; chemistry; Povidone; administration & dosage; analogs & derivatives; chemistry; Solubility; Starch; chemistry; Tablets
- From: Acta Pharmaceutica Sinica 2004;39(6):472-476
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo prepare nifedipine (NP) rapid release mini-tablet, sustained release mini-tablets, pulsed release mini-tablets and delayed-onset sustained release mini-tablets and develop multiplied pulsed drug delivery system (DDS), site-specific DDS, zero-order DDS and quick/slow DDS by various ways.
METHODSVelocity-time (v-t) equation of each mini-tablet was deduced by non-linear least square model fit. The difference of combinations in v-t profiles between theoretical value and test value was compared.
RESULTSAccording to the v-t equations, the combined release behaviors were observed directly from v-t profiles and the test values coincided with the theoretical profiles.
CONCLUSIONThe programmed DDS, which consist of a variety of mini-tablets with different dosages and combinations in capsules, could be predicted by summing up the v-t equation of each tablet.
