Synthesis and anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives.
- Author:
Yong-Jun LOU
1
;
Jin-Hua DONG
;
Li-Ying XU
;
Zhi-Zhong JI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents, Non-Steroidal; chemical synthesis; chemistry; pharmacology; Ear; pathology; Ear Diseases; chemically induced; pathology; Edema; chemically induced; pathology; Male; Mice; Molecular Structure; Sulfonamides; chemical synthesis; chemistry; pharmacology; Xylenes
- From: Acta Pharmaceutica Sinica 2004;39(7):518-520
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives.
METHODSThe target compounds were synthesized from p-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice.
RESULTSEleven compounds were obtained and confirmed by IR, 1HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity.
CONCLUSIONN-(4-arylamidophenyl) methanesulfonamide showed appreciable anti-inflammatory activity.
