Synthesis and antitumor activities of 10-hydroxy camptothecin derivatives.
- Author:
Qing-Yong LI
1
;
Yuan-Gang ZU
;
Ying ZHANG
;
Yu-Jie FU
;
Qun LIU
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; chemical synthesis; chemistry; pharmacology; Camptothecin; analogs & derivatives; chemical synthesis; chemistry; pharmacology; Cell Line, Tumor; Humans; Molecular Structure
- From: Acta Pharmaceutica Sinica 2004;39(7):521-524
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo find new anticancer drug based on the structure of 10-hydroxy camptothecin.
METHODSSeven camptothecin derivatives (3 -9) were synthesized and the antitumor activities of these derivatives were evaluated.
RESULTSStructures of seven new compounds were determined by 1HNMR, IR, MS. Seven compounds showed inhibitory effects on Hela, BEL-7402, 7901 cell lines in vitro. Especially, compound 4 showed high bioactivities to all of the tumor cells in vitro, its anticancer activity against human cervical carcinoma Hela was much higher than that of 10-hydroxy camptothecin.
CONCLUSIONSome compounds are worth further studying.
