Pharmacokinetics of m-nifedipine in Beagle dogs.
- Author:
Zhi-fu YANG
1
;
Si-yuan ZHOU
;
Tie-hong YANG
;
Qi-bing MEI
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Area Under Curve; Biological Availability; Calcium Channel Blockers; administration & dosage; pharmacokinetics; Dogs; Injections, Intravenous; Isomerism; Nifedipine; administration & dosage; pharmacokinetics
- From: Acta Pharmaceutica Sinica 2004;39(8):609-612
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the pharmacokinetics of m-nifedipine (m-Nif) in Beagle dogs.
METHODSThe Beagle dogs were divided into two groups. m-Nif was intravenously administered to the Beagle dogs in group 1 at the dose of 0. 288 mg x kg(-1), and it was orally administered to the Beagle dogs in group 2, 3 and 4 at the dose of 1.152, 3.456 and 10.370 mg x kg(-1), respectively. m-Nif in plasma was detected by reversed phase high performance liquid chromatography. The pharmacokinetic parameters were calculated by 3P97 software.
RESULTSWhen m-Nif was intravenously administered, the plasma concentration-time curve was fit to a two-compartment model and T1/2beta was 117 min. When m-Nif was orally administered, the plasma concentration-time curve was fit to a one-compartment model. T1/2 (Ke) and Cmax were 147 min and 20 microg x L(-1); at the low dose of 1.152 mg x kg(-1). T1/2 (Ke) was 122 min and Cmax was 36 microg x L(-1) at the middle dose of 3.456 mg x kg(-1). T1/2 (Ke) was 144 min and Cmax was 69 microg x L(-1) at the high dose of 10.37 mg x kg(-1), respectively.
CONCLUSIONIt was showed that the speed of elimination of m-Nif was high in Beagle dogs. The absolute bioavailability of m-Nif given orally was very low.
