Characterization of Me. PEG-PLA copolymer nanoparticles prepared by modified spontaneous emulsion-solvent evaporation.
- Author:
Jing DONG
1
;
Ming-xing LIU
;
Ya-jiang YANG
;
Hui-bi XU
;
Xiang-liang YANG
Author Information
- Publication Type:Journal Article
- MeSH: Drug Carriers; Drug Compounding; methods; Emulsions; Microscopy, Atomic Force; Nanotechnology; Particle Size; Polyesters; chemical synthesis; chemistry; Polyethylene Glycols; chemical synthesis; chemistry
- From: Acta Pharmaceutica Sinica 2004;39(9):677-680
- CountryChina
- Language:Chinese
-
Abstract:
AIMCharacterization of poly (D, L-lactic acid)/monomethylether terminated/polyethylene glycol (Me. PEG-PLA) block copolymers nanoparticles.
METHODSMe. PEG-PLA block copolymers were prepared by bulk polymerization. A series of nanoparticles were made from Me. PEG-PLA block copolymer by modified spontaneous emulsion-solvent evaporation technique.
RESULTS AND CONCLUSIONThe structure of copolymer was performed by means of 1HNMR and FT-IR. The morphological examination of nanoparticles was performed by means of atomic force microscope (AFM). Results indicated that nanoparticles exhibited a smooth spherulite and core-shell structure. The hydrophilic shell is consisted of PEG segments and hydrophobic core is consisted of PLA segments. Zeta potential of nanoparticles was zero and further indicated core-shell structure. The particle size and size distribution of nanoparticles were measured by laser light scattering technique. The effective particle size range was from 70 to 160 nm and showed a normal distribution.
